The term area Iam (macaque) refers to the medial agranular insular area, a subdivision of the orbitomedial prefrontal cortex (macaque). It is defined on the basis of internal structure and connectivity. Located in the posterior part of the orbital gyri, Iam is one of two areas in the medial agranular insular region. The other is area Iapm (macaque). Iam is differentiated from some neighboring areas by diffuse lamination with no lamina rara revealed by Nissl stain and a band densely stained for cholinesterase in the internal pyramidal layer (V) ( Carmichael-1994 ). Its equivalent in the human is area Iam ( Ongur-2003 ). As a component of insulo-orbital cortex, its equivalent in the rat and mouse would be in the agranular insular cortex.