The term area Iapl (macaque) refers to the posterolateral agranular insular area of the orbitomedial prefrontal cortex (macaque). It is defined on the basis of internal structure and connectivity. Located in the posterior portion of the orbital gyri, area Iapl is one of three subdivisions of the lateral agranular insular region. Identifying structural features of area Iapl are two bands revealed by Timm stain, intensely in the external pyramidal layer (II/III) and lightly in the internal pyramidal layer (V). The other two lateral agranular areas are area Ial (macaque) and area Iai (macaque) ( Carmichael-1994 ). An equivalent to area Iapl (macaque) has not been reported in the human. Authors of the human study, however, indicate that an equivalent in the human may have been located beyond the portion of cortex they evaluated ( Ongur-2003 ). As a component of insulo-orbital cortex, its equivalent in the rat and mouse would be in the agranular insular cortex.