In this chapter the authors briefly introduce the history and problems of neuroscientific nomenclatures and ontologies as well as the obstacles a person faces while searching for neuroscientific information. They describe three basic kinds of models to which most neuroanatomical terms belong: partitive hierarchies, categorical hierarchies and systemic models. The use of different terms and images to represent the same concept as well as the continual evolution of models demand searchable databases that can handle equivalent representations of the same concept. The authors propose possible designs for such databases and give examples of existing web sites that already use these designs. Another way to efficiently communicate neuroscientific information is using images as overlays to a template atlas. It is not necessary to include all nomenclatures and models of the brain in a contemporary database; many are obsolete or too little used to be of interest. It is essential to design a database that can accommodate future additions and be interoperable with other sources of information. John Wiley & Sons