perforant path (pp)

The term perforant path refers to a pathway that originates in the entorhinal cortex and terminates in the dentate gyrus and the CA fields. In the rat ( Swanson-2004 ), part of the pathway originates in layer II of the entorhinal cortex and projects through the subiculum into the dentate gyrus and the CA3 field of the CA fields. The part that orginates in layer III projects into the subiculum and the CA1 field. In the mouse ( Dong-2004 ), the perforant path originates in layer III of the entorhinal cortex and projects into the CA1 field, CA3 field and the subiculum ( Witter-2000 ).

Also known as: perforant path, perforant pathway

NeuroNames ID: 2686

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perforant path
English
perforant path
English
perforant pathway
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Species With The Structure
Equivalent By Human Macaque Rat Mouse
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perforant path
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perforant path
Models Where It Appears
Functional CNS Model - Rat

The Functional CNS Model - Rat (FMrat) ( Swanson-2004) is one of three hierarchical models representing the internal organization of the central nervous system (CNS). The others are the Structural CNS Model - Human (SThmn) and the Functional CNS Model - Human (FMhmn). The FMrat model represents the basic organization of the mouse ( Hof-2000 AMBA-2024 ) and, presumably, other rodents. Functional CNS models differ from structural models in that structures are defined and named by connectivity rather than by proximity to other structures at the same level. Functional models are more useful for representing longitudinal components of are grouped based on information drawn from multiple neuroscientific disciplines. such as connections, neurochemical characteristics, and role in physiogical and behavioral processes. While the Functional Model was developed primarily for an atlas of the rat brain ( Swanson-2004 ), the hierarchical organization of structures is for the most part applicable to the human, macaque, mouse and other mammalian brains as well. Structures at lower levels of the Functional CNS hierarchy are largely the same as in the Classical and Developmental Models, i.e., they were originally identified by stains for gray matter (Nissl substance) and white matter (myelin). At the next higher level they are grouped into basic connectional and functional systems of the CNS, such as the subcortical sensory systems, the brainstem motor system and the behavioral state system. At the highest levels CNS structures are grouped on the basis of dissection and embryologic precursors into cerebrum ( cerebral cortex and cerebral nuclei ), cerebellum, and cerebrospinal trunk.