pedunculopontine nucleus (PPN)

The term pedunculopontine nucleus (PPN) refers to one of two parts of the midbrain reticular formation (MBRF) identified by histology in the human ( Carpenter-1983 ), macaque ( Oertel-1969 ), rat ( Swanson-2004 ) and mouse ( Hof-2000 ). It is located at the border of the the midbrain (MBR) and the pons (PON), dorsal to the decussation of the superior cerebellar peduncle (scpx) and lateral to the periaqueductal gray (PAG).

Also known as: pedunculopontine tegmental nucleus, Nucleus tegmenti pedunculopontinus, Nucleus pedunculopontinus, pedunculopontine nucleus, peduncular pontine nucleus, pedunculotegmental nucleus, Nucleus tegmentalis pedunculopontinus

NeuroNames ID: 504

All Names & Sources

Showing 20 synonym(s)

Name:

nucleo peduncolopontino

Language:

Italian

Organism:

human

Citation:

EdiSes, s.r.l.- Napoli, 1995

Source Title:

Fondamenti di Neuroanatomia

Name:

nukleus pedunkulopontin pada tegmentum otak-tengah

Language:

Indonesian

Organism:

human

Source:

Noback-1982

Citation:

Jakarta: Penerbit Buku Kedokteran EGC, 1982

Source Title:

Anatomi Susunan Saraf Manusia, Prinsip-Prinsip Dasar Neurobiologi

Name:

pedunculopontine tegmental nucleus

Language:

English

Organism:

human

Citation:

Baltimore: Williams and Wilkins Co., 1983

Source Title:

Human Neuroanatomy

Name:

pedunculopontine tegmental nucleus

Language:

English

Organism:

Macaca fascicularis

Source:

Martin-1997

Citation:

Primate Information Center, University of Washington, Seattle, 1997.

Source Title:

Template Atlas of the Primate Brain

Name:

pedunculopontine tegmental nucleus

Language:

English

Organism:

rat

Source:

Bowden-1997

Citation:

Source Title:

A digital Rosetta stone for primate brain terminology

Name:

Nucleus tegmenti pedunculopontinus

Language:

Latin

Organism:

human

Source:

Crosby-1962

Citation:

New York: MacMillan, 1962

Source Title:

Correlative Anatomy of the Nervous System

Name:

Nucleus tegmenti pedunculopontinus

Language:

Latin

Organism:

Macaca mulatta

Source:

Oertel-1969

Citation:

Journal fuer Hirnforschung 11: pp. 377-405, 1969

Source Title:

Zur zyto- und myeloarchitektonik des Rhombencephalon des Rhesusaffen (Macaca mulatta Zimmerman)

Name:

Nucleus pedunculopontinus

Language:

Latin

Organism:

human

Citation:

Baltimore: Williams and Wilkins Co., 1983

Source Title:

Human Neuroanatomy

Name:

pedunculopontine nucleus

Language:

English

Organism:

human

Citation:

Baltimore: Williams and Wilkins Co., 1983

Source Title:

Human Neuroanatomy

Name:

pedunculopontine nucleus

Language:

English

Organism:

rat

Source:

Bowden-1997

Citation:

Source Title:

A digital Rosetta stone for primate brain terminology

Name:

peduncular pontine nucleus

Language:

English

Organism:

human

Source:

Crosby-1962

Citation:

New York: MacMillan, 1962

Source Title:

Correlative Anatomy of the Nervous System

Name:

PPTg

Language:

acronym

Organism:

macaque

Source:

Martin-2000

Citation:

Elsevier, Amsterdam, 2000

Source Title:

Primate Brain Maps: Structure Of The Macaque Brain

Name:

PPN

Language:

acronym

Organism:

mouse

Source:

Hof-2000

Citation:

Elsevier, Amsterdam, 2000

Source Title:

Comparative Cytoarchitectonic Atlas of the C57BL/6 and 129/Sv Mouse Brains

Name:

PPN

Language:

acronym

Organism:

rat

Source:

Swanson-2004

Citation:

Third Edition, Elsevier Academic Press, Oxford, 2004

Source Title:

Brain Maps: Structure of the Rat Brain.

Name:

pedunculotegmental nucleus

Language:

English

Organism:

macaque

Citation:

Amsterdam: Elsevier-Academic Press. 2009

Source Title:

The Rhesus Monkey Brain, Second Edition

Name:

PTg

Language:

acronym

Organism:

macaque

Citation:

Amsterdam: Elsevier-Academic Press. 2009

Source Title:

The Rhesus Monkey Brain, Second Edition

Name:

PP--PTg

Language:

acronym

Organism:

Unspecified

Source:

Afifi-2005

Citation:

Second Edition, McGraw-Hill Professional, New York, 2005

Source Title:

Functional Neuroanatomy

Name:

Ch5

Language:

acronym

Organism:

Unspecified

Source:

Citation:

Source Title:

Name:

PPT

Language:

acronym

Organism:

Unspecified

Source:

Citation:

Source Title:

Name:

Nucleus tegmentalis pedunculopontinus

Language:

Latin

Organism:

Source:

Citation:

Source Title:

Species With The Structure
Equivalent By Human Macaque Rat Mouse
Topology Has The Structure Has The Structure Has The Structure Relevant Data Not Located

Showing 9 record(s)

Basis:

Topology

Has Equivalent:

Yes

Their Name:

Nucleus pedunculopontinus

Basis:

Topology

Has Equivalent:

Yes

Their Name:

Nucleus tegmenti pedunculopontinus

Source:

Crosby-1962

Basis:

Topology

Has Equivalent:

Yes

Their Name:

peduncular pontine nucleus

Source:

Crosby-1962

Basis:

Topology

Has Equivalent:

Yes

Their Name:

pedunculopontine nucleus

Basis:

Topology

Has Equivalent:

Yes

Their Name:

pedunculopontine tegmental nucleus

Basis:

Topology

Has Equivalent:

Yes

Their Name:

pedunculopontine tegmental nucleus

Source:

Martin-1997

Basis:

Topology

Has Equivalent:

Yes

Their Name:

Nucleus tegmenti pedunculopontinus

Source:

Oertel-1969

Basis:

Topology

Has Equivalent:

Yes

Organism:

Rattus (rat)

Their Name:

pedunculopontine nucleus

Source:

Bowden-1997

Basis:

Topology

Has Equivalent:

Yes

Organism:

Rattus (rat)

Their Name:

pedunculopontine tegmental nucleus

Source:

Bowden-1997

Models Where It Appears
Structural CNS Model - Macaque

Brain structures of the macaque are illustrated in BrainInfo’s NeuroMaps macaque brain atlas. Structures are grouped by proximity in a hierarchy corresponding to the central nervous system hierarchy of NeuroNames ( Bowden-1995 Martin-2000 ). Structures in the NeuroMaps atlas are based on the segmentation of an MRI of the brain of a 3-year old male rhesus macaque (Macaca mulatta). The atlas is most useful for targeting structures for implantating electrodes and chemtrodes. Updated 29 Oct 2025.

Functional CNS Model - Rat

The Functional CNS Model - Rat (FMrat) ( Swanson-2004) is one of three hierarchical models representing the internal organization of the central nervous system (CNS). The others are the Structural CNS Model - Human (SThmn) and the Functional CNS Model - Human (FMhmn). The FMrat model represents the basic organization of the mouse ( Hof-2000 AMBA-2024 ) and, presumably, other rodents. Functional CNS models differ from structural models in that structures are defined and named by connectivity rather than by proximity to other structures at the same level. Functional models are more useful for representing longitudinal components of are grouped based on information drawn from multiple neuroscientific disciplines. such as connections, neurochemical characteristics, and role in physiogical and behavioral processes. While the Functional Model was developed primarily for an atlas of the rat brain ( Swanson-2004 ), the hierarchical organization of structures is for the most part applicable to the human, macaque, mouse and other mammalian brains as well. Structures at lower levels of the Functional CNS hierarchy are largely the same as in the Classical and Developmental Models, i.e., they were originally identified by stains for gray matter (Nissl substance) and white matter (myelin). At the next higher level they are grouped into basic connectional and functional systems of the CNS, such as the subcortical sensory systems, the brainstem motor system and the behavioral state system. At the highest levels CNS structures are grouped on the basis of dissection and embryologic precursors into cerebrum ( cerebral cortex and cerebral nuclei ), cerebellum, and cerebrospinal trunk.