presubiculum (PRSB)

The term presubiculum refers to a histologically and functionally defined structure in the hippocampal formation (HPF) of the human, macaque, rat and mouse. In the human it is located in the anterior parahippocampal gyrus ventral to the subiculum and dorsal to the posterior parahippocampal cortex ( Glasser-2016 ). In the macaque it is located lateral to the subiculum and medial to the parasubiculum on the dorsal surface of both the anterior parahippocampal gyrus and the posterior parahippocampal gyrus ( Paxinos-2009a ). . In the rat it is located on the mesial surface of the caudal part of cerebral cortex between the postsubiculum dorsally and the subiculum ventrally. Further posteriorly, it is bounded ventrally by the parasubiculum ( Swanson-2004 ). In the mouse, It is rostraly bounded dorsally by the retrosplenial cortex and ventrally by the subiculum; further caudally the ventral boundary is, as in the rat, with the parasubiculum ( Hof-2000 ). Functionally the PRSB is involved in head direction ( Simonnet-2018 ). Considering that it is part of the HPF, it is presumably nvolved in the more general control of orienting and attention to the onset of novel, potentially significant stimuli and to the unexpected onset of significant familiar stimuli. Repetitive exposure to such stimuli results in habituation of the orienting response and recording of a memory of the stimulus. ( Vinogradova-2001 ). Updated 4 Jun 2024.

Also known as: Area praesubicularis, presubiculum, Presubiculum, Praesubiculum, presubiculum (Cajal), area 27 of Brodmann (human)

NeuroNames ID: 167

All Names & Sources

Showing 17 synonym(s)

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English
area 27 of Brodmann (human)
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presubiculum
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presubiculum
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presubiculum
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presubiculum (Cajal)
Species With The Structure
Equivalent By Human Macaque Rat Mouse
Internal Structure Has The Structure Has The Structure Has The Structure Relevant Data Not Located

Showing 8 record(s)

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area 27 of Brodmann (human)
Internal Structure
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Area praesubicularis
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Praesubiculum
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presubiculum
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Presubiculum
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presubiculum
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presubiculum
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presubiculum (Cajal)
Models Where It Appears
Structural CNS Model - Macaque

Brain structures of the macaque are illustrated in BrainInfo’s NeuroMaps macaque brain atlas. Structures are grouped by proximity in a hierarchy corresponding to the central nervous system hierarchy of NeuroNames ( Bowden-1995 Martin-2000 ). Structures in the NeuroMaps atlas are based on the segmentation of an MRI of the brain of a 3-year old male rhesus macaque (Macaca mulatta). The atlas is most useful for targeting structures for implantating electrodes and chemtrodes. Updated 29 Oct 2025.

Functional CNS Model - Rat

The Functional CNS Model - Rat (FMrat) ( Swanson-2004) is one of three hierarchical models representing the internal organization of the central nervous system (CNS). The others are the Structural CNS Model - Human (SThmn) and the Functional CNS Model - Human (FMhmn). The FMrat model represents the basic organization of the mouse ( Hof-2000 AMBA-2024 ) and, presumably, other rodents. Functional CNS models differ from structural models in that structures are defined and named by connectivity rather than by proximity to other structures at the same level. Functional models are more useful for representing longitudinal components of are grouped based on information drawn from multiple neuroscientific disciplines. such as connections, neurochemical characteristics, and role in physiogical and behavioral processes. While the Functional Model was developed primarily for an atlas of the rat brain ( Swanson-2004 ), the hierarchical organization of structures is for the most part applicable to the human, macaque, mouse and other mammalian brains as well. Structures at lower levels of the Functional CNS hierarchy are largely the same as in the Classical and Developmental Models, i.e., they were originally identified by stains for gray matter (Nissl substance) and white matter (myelin). At the next higher level they are grouped into basic connectional and functional systems of the CNS, such as the subcortical sensory systems, the brainstem motor system and the behavioral state system. At the highest levels CNS structures are grouped on the basis of dissection and embryologic precursors into cerebrum ( cerebral cortex and cerebral nuclei ), cerebellum, and cerebrospinal trunk.