presubiculum - BrainInfo

presubiculum (PRSB)

The term presubiculum refers to a histologically and functionally defined structure in the hippocampal formation (HPF) of the human, macaque, rat and mouse. In the human it is located in the anterior parahippocampal gyrus ventral to the subiculum and dorsal to the posterior parahippocampal cortex ( Glasser-2016 ). In the macaque it is located lateral to the subiculum and medial to the parasubiculum on the dorsal surface of both the anterior parahippocampal gyrus and the posterior parahippocampal gyrus ( Paxinos-2009a ). . In the rat it is located on the mesial surface of the caudal part of cerebral cortex between the postsubiculum dorsally and the subiculum ventrally. Further posteriorly, it is bounded ventrally by the parasubiculum ( Swanson-2004 ). In the mouse, It is rostraly bounded dorsally by the retrosplenial cortex and ventrally by the subiculum; further caudally the ventral boundary is, as in the rat, with the parasubiculum ( Hof-2000 ). Functionally the PRSB is involved in head direction ( Simonnet-2018 ). Considering that it is part of the HPF, it is presumably nvolved in the more general control of orienting and attention to the onset of novel, potentially significant stimuli and to the unexpected onset of significant familiar stimuli. Repetitive exposure to such stimuli results in habituation of the orienting response and recording of a memory of the stimulus. ( Vinogradova-2001 ). Updated 4 Jun 2024.

Also known as: Area praesubicularis, presubiculum, Presubiculum, Praesubiculum, presubiculum (Cajal), area 27 of Brodmann (human)

NeuroNames ID: 167

All Names & Sources

1 of 17

Showing 17 synonym(s) - Use arrows to navigate

Showing 17 synonym(s)

Name:

PRE

Language:

acronym

Organism:

rat

Source:

Swanson-1998

Citation:

Second Revised Edition, Elsevier Science, Amsterdam, 1998

Source Title:

Brain Maps: Structure of the Rat Brain

Name:

Area praesubicularis

Language:

Latin

Organism:

human

Source:

Brodmann-1909

Citation:

IV. Kapitel in Vergleichende Lokalisationslehre der Grosshirnrinde (Leipzig: Verlag von Johann Ambrosias Barth), 1909

Source Title:

Beschreibung der einzelnen Hirnkarten

Name:

PrS

Language:

acronym

Organism:

human

Source:

Mai-1997

Citation:

San Diego: Academic Press, 1997

Source Title:

Atlas of the Human Brain

Name:

presubiculum

Language:

English

Organism:

human

Source:

Carpenter-1983

Citation:

Baltimore: Williams and Wilkins Co., 1983

Source Title:

Human Neuroanatomy

Name:

presubiculum

Language:

English

Organism:

Macaca fascicularis

Source:

Martin-1997

Citation:

Primate Information Center, University of Washington, Seattle, 1997.

Source Title:

Template Atlas of the Primate Brain

Name:

Presubiculum

Language:

Latin

Organism:

human

Source:

Crosby-1962

Citation:

New York: MacMillan, 1962

Source Title:

Correlative Anatomy of the Nervous System

Name:

presubiculum

Language:

English

Organism:

rat

Source:

Bowden-1997

Citation:

Source Title:

A digital Rosetta stone for primate brain terminology

Name:

Praesubiculum

Language:

Latin

Organism:

human

Source:

Mai-1997

Citation:

San Diego: Academic Press, 1997

Source Title:

Atlas of the Human Brain

Name:

PRS

Language:

acronym

Organism:

mouse

Source:

Hof-2000

Citation:

Elsevier, Amsterdam, 2000

Source Title:

Comparative Cytoarchitectonic Atlas of the C57BL/6 and 129/Sv Mouse Brains

Name:

presubiculum

Language:

Italian

Organism:

human

Source:

Carpenter-1995

Citation:

EdiSes, s.r.l.- Napoli, 1995

Source Title:

Fondamenti di Neuroanatomia

Name:

Feld 27

Language:

German

Organism:

human

Source:

Brodmann-1909

Citation:

IV. Kapitel in Vergleichende Lokalisationslehre der Grosshirnrinde (Leipzig: Verlag von Johann Ambrosias Barth), 1909

Source Title:

Beschreibung der einzelnen Hirnkarten

Name:

Area praesubicularis

Language:

Latin

Organism:

guenon

Source:

Brodmann-1909

Citation:

IV. Kapitel in Vergleichende Lokalisationslehre der Grosshirnrinde (Leipzig: Verlag von Johann Ambrosias Barth), 1909

Source Title:

Beschreibung der einzelnen Hirnkarten

Name:

Feld 27

Language:

German

Organism:

guenon

Source:

Brodmann-1909

Citation:

IV. Kapitel in Vergleichende Lokalisationslehre der Grosshirnrinde (Leipzig: Verlag von Johann Ambrosias Barth), 1909

Source Title:

Beschreibung der einzelnen Hirnkarten

Name:

presubiculum (Cajal)

Language:

English

Organism:

rat

Source:

Swanson-1998

Citation:

Second Revised Edition, Elsevier Science, Amsterdam, 1998

Source Title:

Brain Maps: Structure of the Rat Brain

Name:

area 27 of Brodmann (human)

Language:

English

Organism:

human

Source:

Brodmann-1909

Citation:

IV. Kapitel in Vergleichende Lokalisationslehre der Grosshirnrinde (Leipzig: Verlag von Johann Ambrosias Barth), 1909

Source Title:

Beschreibung der einzelnen Hirnkarten

Name:

PrS

Language:

acronym

Organism:

Macaca mulatta

Source:

Paxinos-2009a

Citation:

Amsterdam: Elsevier-Academic Press. 2009

Source Title:

The Rhesus Monkey Brain, Second Edition

Name:

PRSB

Language:

acronym

Organism:

Unspecified

Source:

NeuroNames

Citation:

University of Washington, Seattle, WA

Source Title:

NeuroNames

Illustrations

Showing 4 illustration(s)

labeled line drawings of
sagittal section in
Macaca fascicularis

multiple views of
3D reconstruction in
Macaca mulatta

Nissl stain & diagram of
coronal section in
mouse

Nissl stain & diagram of
sagittal section in
mouse

Species With The Structure

Equivalent By	Human	Macaque	Rat	Mouse
Internal Structure	Has The Structure	Has The Structure	Has The Structure	Relevant Data Not Located

1 of 8

Showing 8 record(s) - Use arrows to navigate

Showing 8 record(s)

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Homo sapiens (human)

Their Name:

area 27 of Brodmann (human)

Source:

Brodmann-1909

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Homo sapiens (human)

Their Name:

Area praesubicularis

Source:

Brodmann-1909

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Homo sapiens (human)

Their Name:

Praesubiculum

Source:

Mai-1997

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Homo sapiens (human)

Their Name:

presubiculum

Source:

Carpenter-1983

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Homo sapiens (human)

Their Name:

Presubiculum

Source:

Crosby-1962

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Macaca fascicularis (Macaca fascicularis)

Their Name:

presubiculum

Source:

Martin-1997

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Rattus (rat)

Their Name:

presubiculum

Source:

Bowden-1997

Basis:

Internal Structure

Has Equivalent:

Yes

Organism:

Rattus (rat)

Their Name:

presubiculum (Cajal)

Source:

Swanson-1998

Models Where It Appears

Structural CNS Model - Macaque

Brain structures of the macaque are illustrated in BrainInfo’s NeuroMaps macaque brain atlas. Structures are grouped by proximity in a hierarchy corresponding to the central nervous system hierarchy of NeuroNames ( Bowden-1995 Martin-2000 ). Structures in the NeuroMaps atlas are based on the segmentation of an MRI of the brain of a 3-year old male rhesus macaque (Macaca mulatta). The atlas is most useful for targeting structures for implantating electrodes and chemtrodes. Updated 29 Oct 2025.

brain

forebrain

endbrain

cerebral white matter

substantia innominata

basal nucleus (basal forebrain nucleus)

islands of Calleja

nucleus accumbens

anterior olfactory nucleus

olfactory tubercle

main olfactory bulb (olfactory bulb)

olfactory peduncle (olfactory tract)

telodiencephalic fissure

midbrain

hindbrain

choroidal fissure

Functional CNS Model - Rat

The Functional CNS Model - Rat (FMrat) ( Swanson-2004) is one of three hierarchical models representing the internal organization of the central nervous system (CNS). The others are the Structural CNS Model - Human (SThmn) and the Functional CNS Model - Human (FMhmn). The FMrat model represents the basic organization of the mouse ( Hof-2000 AMBA-2024 ) and, presumably, other rodents. Functional CNS models differ from structural models in that structures are defined and named by connectivity rather than by proximity to other structures at the same level. Functional models are more useful for representing longitudinal components of are grouped based on information drawn from multiple neuroscientific disciplines. such as connections, neurochemical characteristics, and role in physiogical and behavioral processes. While the Functional Model was developed primarily for an atlas of the rat brain ( Swanson-2004 ), the hierarchical organization of structures is for the most part applicable to the human, macaque, mouse and other mammalian brains as well. Structures at lower levels of the Functional CNS hierarchy are largely the same as in the Classical and Developmental Models, i.e., they were originally identified by stains for gray matter (Nissl substance) and white matter (myelin). At the next higher level they are grouped into basic connectional and functional systems of the CNS, such as the subcortical sensory systems, the brainstem motor system and the behavioral state system. At the highest levels CNS structures are grouped on the basis of dissection and embryologic precursors into cerebrum ( cerebral cortex and cerebral nuclei ), cerebellum, and cerebrospinal trunk.

gray matter (central nervous system gray matter)

white matter (basic fiber systems)

cerebral ventricles (ventricular system)